Description
C16 Phytoceramide (t18:0/16:0) is a phytoceramide, which is a family of sphingolipids found in the intestine, kidney, and extracellular spaces of the stratum corneum of the mammalian epidermis. C16 Phytoceramide (t18:0/16:0) is composed of a phytosphingosine backbone amine-linked to a C16 fatty acid chain. The levels of C16 phytoceramide (t18:0/16:0) increase following heat stress in
S. cerevisiae. It has been used with other ceramides to create stratum corneum substitutes to study percutaneous penetration and psoriasis
in vitro. [Matreya, LLC. Catalog No. 2035]
References
[1] M. W. CROSSMAN C H. Biosynthesis of phytosphingosine by the rat.[J]. The Journal of Biological Chemistry, 1977, 22 1: 5815-5819. DOI:
10.1016/s0021-9258(17)40095-0[2] YUKIKO MIZUTANI Yasuyuki I Akio Kihara. Identification of the human sphingolipid C4-hydroxylase, hDES2, and its up-regulation during keratinocyte differentiation[J]. FEBS Letters, 2004, 563 1: Pages 93-97. DOI:
10.1016/s0014-5793(04)00274-1[3] DAVID J. MONTEFUSCO. Distinct Signaling Roles of Ceramide Species in Yeast Revealed Through Systematic Perturbation and Systems Biology Analyses[J]. Science Signaling, 2013, 6 299. DOI:
10.1126/scisignal.2004515[4] MIRANDA DE JAGER . Preparation and characterization of a stratum corneum substitute for in vitro percutaneous penetration studies[J]. Biochimica et biophysica acta. Biomembranes, 2006, 1758 5: Pages 636-644. DOI:
10.1016/j.bbamem.2006.04.001[5] LINE HOLLESEN BASSE Joke A B Danil Groen. Permeability and lipid organization of a novel psoriasis stratum corneum substitute[J]. International Journal of Pharmaceutics, 2013, 457 1: Pages 275-282. DOI:
10.1016/j.ijpharm.2013.08.086
