2-Methyl-3-nitrobenzotrifluoride

Chemical Properties

Colorless to light yellow Liquid

Uses

2-Methyl-3-nitrobenzotrifluoride serves as a precursor for synthesizing 2-Nitro-6-(trifluoromethyl)benzyl bromide via bromination with N-bromosuccinimide and benzoyl peroxide under reflux[1]. It is also used as a starting material in the synthesis of the LDH inhibitor NHI-Glc-2[2].

References

[1] Houlihan, F. M., Neenan, T. X., Reichmanis, E., Kometani, J. M., Chin, T. (1991). Design, synthesis, characterization, and use of all-organic, nonionic photogenerators of acid. Chemistry of Materials, 3(3), 462–471. https://doi.org/10.1021/cm00015a020
[2] Apicella, M., Giannoni, E., Fiore, S., Ferrari, K. J., Fernández-Pérez, D., Isella, C., Granchi, C., Minutolo, F., Sottile, A., Comoglio, P. M., Medico, E., Pietrantonio, F., Volante, M., Pasini, D., Chiarugi, P., Giordano, S., Corso, S. (2018). Increased Lactate Secretion by Cancer Cells Sustains Non-cell-autonomous Adaptive Resistance to MET and EGFR Targeted Therapies. Cell Metabolism, 28(6), 848–865.e6. https://doi.org/10.1016/j.cmet.2018.08.006