Description
MMP-8 Inhibitor I is a selective inhibitor of the neutrophil collagenase matrix metalloproteinase-8 (MMP-8) with an IC
50 value of 4 nM. This inhibitor does not target the activities of other MMPs
in vitro. MMP-8 cleaves interstitial collagens and has exhibited activity in atherosclerotic plaques, angiogenesis, and stem cell mobilization. Additionally, MMP-8 expression is observed in normal mammary epithelial cells, whereas a loss of expression is observed in human ductal carcinoma
in situ and the deletion of MMP-8 accelerates tumor onset in a mouse model of aggressive breast cancer.
References
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10.1007/s11999-008-0596-6[3] GERALD W PRAGER. Vascular endothelial growth factor (VEGF) induces rapid prourokinase (pro-uPA) activation on the surface of endothelial cells.[J]. Blood, 2004, 103 3: 955-962. DOI:
10.1182/blood-2003-07-2214[4] QISHAN CHEN. Matrix metalloproteinases: inflammatory regulators of cell behaviors in vascular formation and remodeling.[J]. Mediators of Inflammation, 2013: 928315. DOI:
10.1155/2013/928315[5] JULIE DECOCK. Pleiotropic functions of the tumor- and metastasis-suppressing matrix metalloproteinase-8 in mammary cancer in MMTV-PyMT transgenic mice.[J]. Breast Cancer Research: BCR, 2015: 38. DOI:
10.1186/s13058-015-0545-8[6] MUGE SARPER. Loss of MMP-8 in ductal carcinoma in situ (DCIS)-associated myoepithelial cells contributes to tumour promotion through altered adhesive and proteolytic function.[J]. Breast Cancer Research: BCR, 2017: 33. DOI:
10.1186/s13058-017-0822-9
