1-(4-Hydroxy-2,5-dimethylphenyl)-1-propanone

Preparation

Preparation by Fries rearrangement of 2,5-dimethylphenyl propionate with aluminium chloride,
in nitrobenzene at r.t. for 24 h (70%) or 44 h (41%) ;
in nitromethane at r.t. for 21 days (61%). The same result (61%) was obtained by using titanium tetrachloride as catalyst at r.t. for 7 days;
in nitromethane at 20° for 24 h, but using different quantities of aluminium chloride by mole of ester:
without solvent at 100° for 7 h (36%).