ChemicalBook CAS DataBase List 1H-Benzimidazole-5-carboxamide, 1,1'-(1,4-butanediyl)bis[2-[[(1-ethyl-3-methyl-1H-pyrazol-5-yl)carbonyl]amino]-

1H-Benzimidazole-5-carboxamide, 1,1'-(1,4-butanediyl)bis[2-[[(1-ethyl-3-methyl-1H-pyrazol-5-yl)carbonyl]amino]-

Product Name1H-Benzimidazole-5-carboxamide, 1,1'-(1,4-butanediyl)bis[2-[[(1-ethyl-3-methyl-1H-pyrazol-5-yl)carbonyl]amino]-
CAS2138300-40-8
CBNumberCB45479775
MFC34H38N12O4
MW678.74
MDL NumberMFCD32197200
MOL File2138300-40-8.mol
MSDS FileSDS

Chemical Properties

Density	1.48±0.1 g/cm3(Predicted)
storage temp.	Store at -20°C
solubility	DMSO: slightly soluble
form	A solid
pka	11.97±0.43(Predicted)
color	White to gray
InChIKey	ICZSAXDKFXTSGL-UHFFFAOYSA-N
SMILES	C(N1C(NC(C2N(CC)N=C(C)C=2)=O)=NC2=CC(C(N)=O)=CC=C21)CCCN1C(NC(C2N(CC)N=C(C)C=2)=O)=NC2=CC(C(N)=O)=CC=C21

1H-Benzimidazole-5-carboxamide, 1,1'-(1,4-butanediyl)bis[2-[[(1-ethyl-3-methyl-1H-pyrazol-5-yl)carbonyl]amino]- Price

Product number	Packaging	Price	Product description	Buy
Cayman Chemical 34088	500μg	$69	diABZI STING Agonist 2 ≥98%	Buy
Cayman Chemical 34088	1mg	$127	diABZI STING Agonist 2 ≥98%	Buy
Cayman Chemical 34088	5mg	$525	diABZI STING Agonist 2 ≥98%	Buy
Cayman Chemical 34088	10mg	$918	diABZI STING Agonist 2 ≥98%	Buy
Biosynth NKD30040	10mg	$584.8	Sting agonist-4	Buy

1H-Benzimidazole-5-carboxamide, 1,1'-(1,4-butanediyl)bis[2-[[(1-ethyl-3-methyl-1H-pyrazol-5-yl)carbonyl]amino]- Chemical Properties,Usage,Production

Uses

STING agonist-4 is an stimulator of Interferon Genes (STING) receptor agonist with an apparent inhibitory constant (IC50) of 20 nM. STING agonist-4 is a two symmetry-related amidobenzimidazole (ABZI)-based compound to create linked ABZIs (diABZIs) with enhanced binding to STING and cellular function[1].

Biological Activity

STING agonist-4 is a stimulator of receptor agonists of the interferon gene (STING) with an apparent inhibition constant IC50 of 20 nM, It is a compound containing two symmetrically related aminobenzimidazoles (ABZI ) based compounds.

in vitro

STING agonist-4 (Compound 2) (0.3-30 μM; 2 hours) causes phosphorylation of IRF3 and STING that is inhibited by the TBK1 inhibitor BX795 and induces dose-dependent secretion of IFN-β with an EC ₅₀ of 3.1 μM. STING agonist-4 (Compound 2) (0.001 nM-1 μM) inhibits binding of full-length STING to the solid support with an apparent dissociation constant (K _{d < /sub> ) of approximately 1.6 nM. It (Compound 2) (0-100 μM) is 18-fold more potent than cGAMP (an endogenous STING ligand), with an EC ₅₀ of 53.9 μM. STING agonist-4 (Compound 2) (3 μM; 4 hours) promotes production of interferon γ-induced protein 10 (IP-10), IL-6 and TNF-α by a mechanism that is dependent on STING-mediated activation of TBK1.}

Cell Viability Assay

< td class="col1"> Result:

Cell Line:	Human peripheral blood mononucl ear cells (PBMCs)
Concentration:	0.3 μM, 1 μM, 3 μM, 10 μM and 30 μM
Incubation Time:	2 hours
Caused phosphorylation of IRF3 and STING and induced secretion of IFN-β.

target

IC50: 20 nM (STING agonist-4)

References

[1] Ramanjulu JM et al. Design of amidobenzimidazole STING receptor agonists with systemic activity. Nature. 2018 Dec;564(7736):439-443. DOI:10.1038/s41586-018-0705-y

Preparation Products And Raw materials

1H-Benzimidazole-5-carboxamide, 1,1'-(1,4-butanediyl)bis[2-[[(1-ethyl-3-methyl-1H-pyrazol-5-yl)carbonyl]amino]- Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Suzhou Su Taike Biological Reagent Co., Ltd.	0512-0512-65884469 18352410772	seetech@126.com	China	4	58
ShangHai Caerulum Pharma Discovery Co., Ltd.	18149758185 18149758185	sales-cpd@caerulumpharma.com	China	3493	58
Shanghai Lollane Biological Technology Co.,Ltd.	021-52996696，15000506266 15000506266		China	4865	55
Shanghai EFE Biological Technology Co., Ltd.	021-65675885 18964387627	info@efebio.com	China	9799	58
Beijing Solarbio Science & Tecnology Co., Ltd.	17801761073 18101056239	3193328036@qq.com	China	28149	68
Heze Development Zone chuangli Chemical Co., Ltd.	0530-+86-530-529 6766，+86-15666160102 15666160102	info@chuangli-chem.com	China	906	55
Fan De(Beijing) Biotechnology Co., Ltd.	15911056312	liming@bio-fount.com	China	9718	58
BOC Sciences	--	info@bocsci.com	USA	0	65
InvivoChem	+1-708-310-1919 +1-13798911105	sales@invivochem.cn	United States	6378	58
TargetMol Chemicals Inc.	+1-781-999-5354; +1-00000000000	marketing@targetmol.com	United States	32431	58

1H-Benzimidazole-5-carboxamide, 1,1'-(1,4-butanediyl)bis[2-[[(1-ethyl-3-methyl-1H-pyrazol-5-yl)carbonyl]amino]- Spectrum

2138300-40-8, 1H-Benzimidazole-5-carboxamide, 1,1'-(1,4-butanediyl)bis[2-[[(1-ethyl-3-methyl-1H-pyrazol-5-yl)carbonyl]amino]-Related Search

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