(3S,5R)-3,5-difluoropiperidine hydrochloride

Uses

Fluorinated piperidines are of interest in drugs, agrochemicals and materials science. A straightforward process developed by Glorius and coworkers allows the preparation of these motifs in a highly diastereoselective manner. The all-cis-3,5-difluoropiperidine can be directly employed in synthetic applications after TFA-deprotection.