![DBCO-PEG5-NHS ester Structure](https://www.chemicalbook.com/CAS/20200611/GIF/2144395-59-3.gif)
DBCO-PEG5-NHS ester
- Product NameDBCO-PEG5-NHS ester
- CAS2144395-59-3
- CBNumberCB44849429
- MFC36H43N3O11
- MW693.74
- MDL NumberMFCD22380747
- MOL File2144395-59-3.mol
Chemical Properties
solubility | Soluble in DMSO, DCM, DMF |
DBCO-PEG5-NHS ester Chemical Properties,Usage,Production
Description
DBCO-PEG5-NHS Ester is a DBCO-containing PEG linker containing NHS ester that can react specifically and efficiently with primary amines (e.g. the side chain of lysine residues or aminosilane-coated surfaces) at neutral or slightly basic condition to form a covalent bond. PEG5 spacer increases the water solubility of compounds in aqueous media. DBCO is commonly used for copper-free Click Chemistry reaction.Biological Activity
DBCO-PEG5-NHS ester is a PROTAC linker, belonging to the PEG class and the Alkyl/ether class, for the synthesis of a series of PROTAC molecules. DBCO-PEG5-NHS ester is a cleavable ADC linker for the synthesis of antibody drug conjugates (ADCs).in vitro
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.
target
Cleavable
| Alkyl/ether
| PEGs
|
Preparation Products And Raw materials
DBCO-PEG5-NHS ester Suppliers
Global(25)Suppliers
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
+1-781-999-5354 +1-00000000000 |
marketing@targetmol.com | United States | 19892 | 58 | |
+8618917134367 | lixing@pharmahuici.com | China | 133 | 58 | |
+8618917134367 | lixing@pharmahuici.com | China | 133 | 58 | |
+undefined18143011203 | info@chemextension.com | China | 42057 | 58 | |
+86-15680926068 +86-15680926068 |
1924344760@confluore.cn | China | 2996 | 58 | |
+1-+1(833)-552-7181 | sales@aladdinsci.com | United States | 52927 | 58 | |
021-58088081 Q2816483246 |
hailey@shsendpharm.com | China | 3139 | 55 | |
0431-80514535 19917294565 |
et@chemextension.com | China | 4108 | 55 | |
027-65563561 | sales@borenpharm.com | China | 1246 | 55 | |
010-60605840 18892239720 |
psaitong@jm-bio.com | China | 12308 | 58 |
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