General Description
A cell-permeable triazine compound that directly and reversibly binds to ETS family transcription factor ETV1 (K
D = 17.1 μM) and reduces its transcriptional activity, independent of its binding to DNA. Selectively inhibits p300-dependent ETV1 acetylation at K33 and K116 and thereby promotes its degradation (~50 μM). Inhibits the invasion capacity of ETV1-dependent cell lines and primary melanocytes expressing NRAS
G12D, but not in primary melanocytes expressing NRAS. Does not affect PC3 cell line that is not dependent on ETV1 for invasion. Also it has no effect on the invasion of cancer cells expressing mutated ETV1 (K33R/K116R).
Please note that the molecular weight for this compound is batch-specific due to variable water content.
