Cysteinyl Leukotriene Express ELISA Kit

Description

Leukotrienes (LTs) are a group of acute inflammatory mediators derived from arachidonic acid via the 5-lipoxygenase (5-LO) pathway in leukocytes. LTC₄, LTD₄, and LTE₄ are collectively referred to as cysteinyl leukotrienes (CysLTs). LTC₄ and LTD₄ are potent mediators of asthma and hypersensitivity. They induce bronchoconstriction, increase microvascular permeability, and are vasoconstrictors of coronary arteries. The biological activity of LTE₄ is much lower in most systems studied, but its presence reflects the prior existence of LTC₄ and LTD₄. Cayman’s CysLT Express ELISA Kit is a competitive assay that can be used for measurement of all three primary CysLTs in urine, culture media, and other sample matrices. The assay has a range from 7.8-1,000 pg/ml and a sensitivity (80% B/B₀) value of approximately 20 pg/ml. This sensitive assay takes about three hours to complete.