Description
Candesartan-d
4 is intended for use as an internal standard for the quantification of candesartan by GC- or LC-MS. Candesartan is an antagonist of the angiotensin II type 1 (AT
1) receptor (K
is = 0.17, 0.12, and 0.12 nM for human AT
1, rat AT
1A, and rat AT
1B recombinant receptors, respectively) and an active metabolite of the prodrug candesartan cilexitil (Item No.
10489). It is selective for AT
1 over AT
2 receptors (K
i = 26,500 nM for the human recombinant AT
2 receptor). It inhibits angiotensin II-induced contraction of isolated rabbit aortic strips and increases in blood pressure in rats following intravenous administration (ID
50 = 0.033 mg/kg). Formulations containing candesartan have been used in the treatment of hypertension and heart failure.
