2-Acetoxybenzoic-3,4,5,6-d4 acid

Description

Aspirin-d₄ is intended for use as an internal standard for the quantification of aspirin by GC- or LC-MS. Aspirin is a non-selective, irreversible COX inhibitor. The IC₅₀ values for ovine COX-1 and -2 are 0.75 and 1.25 mM, respectively. Aspirin acetylates COX-1 at Ser⁵³⁰ and COX-2 at Ser⁵¹⁶ resulting in irreversible enzyme inhibition.

Chemical Properties

2-ACETOXYBENZOIC-3,4,5,6-D4 ACID is Off-White Solid

Uses

Labeled Aspirin, intended for use as an internal standard for the quantification of Aspirin by GC- or LC-mass spectrometry.

Uses

Analgesic; antipyretic; anti-inflammatory; antithrombotic

References

[1] BYRON CRYER MD  Mark F M. Cyclooxygenase-1 and Cyclooxygenase-2 Selectivity of Widely Used Nonsteroidal Anti-Inflammatory Drugs[J]. American Journal of Medicine, 1998, 104 5: Pages 413-421. DOI: 10.1016/s0002-9343(98)00091-6
[2] JENNIFER L. JOHNSON . Purification and Characterization of Prostaglandin H Synthase-2 from Sheep Placental Cotyledons[J]. Archives of biochemistry and biophysics, 1995, 324 1: Pages 26-34. DOI: 10.1006/abbi.1995.9934
[3] J PAPP. Antiplatelet effect of acetylsalicylic acid, metamizole and their combination - in vitro and in vivo comparisons.[J]. Clinical hemorheology and microcirculation, 2014, 56 1: 1-12. DOI: 10.3233/ch-2012-1636
[4] SHAWN N WHITEHEAD. Effects of triflusal and aspirin in a rat model of cerebral ischemia.[J]. Stroke, 2007, 38 2: 381-387. DOI: 10.1161/01.str.0000254464.05561.72
[5] T. CYRUS. Effect of Low-Dose Aspirin on Vascular Inflammation, Plaque Stability, and Atherogenesis in Low-Density Lipoprotein Receptor–Deficient Mice[J]. Circulation: Journal of the American Heart Association, 2002, 88 1: 1282-1287. DOI: 10.1161/01.cir.0000027816.54430.96