Uses
Monoclonal Anti-Human Gastric Mucin may be used for the localization of gastric mucin using various immunochemical assays such as immunoblot, immunofluorescence, immunohistochemistry, immunostaining and immunoradiofixation.
Uses
Anti-ETFA (AB1) antibody produced in rabbit is suitable for western blotting at a concentration of 1μg/mL.
General Description
MUC1 (Mucin 1) is O-glycosylated, carbohydrate rich, transmembrane glycoprotein. It has approximately 13 members in the family. It is localized on the apical surface of mucosal epithelia in the lung, eye, breast and stomach. It is overexpressed in several epithelial cancers, including pancreatic ductal adenocarcinoma. It is a heterodimer consisting of N-terminal (MUC1-N) and C-terminal (MUC1-C) subunits. N-terminal (MUC1-N) end contains tandem repeats (VNTR) which forms the mucin component.
Biochem/physiol Actions
ETFA (electron-transfer-flavoprotein, α polypeptide) encodes a flavoprotein that belongs to ETF α-subunit/FixB family. It facilitates the catalysis of initial step of the mitochondrial fatty acid β-oxidation. Increase in the cellular levels of ETFA leads to activation of JNK1/2 and NFκB signaling modules which in turn facilitates the t-BHP induced apoptosis cascade and cell viability.
