t-Boc-N-Amido-PEG2-Ms

Description

t-Boc-N-Amido-PEG2-Ms is a PEG linker that contains a Boc protecting group and a mesyl group. The t-Boc group can be removed under acidic conditions. The mesyl group is a good leaving group for nucleophilic substitution reactions. The hydrophilic PEG spacer increases the water solubility of the compound. Longer PEG chains increase the water solubility properties of the compound.

Uses

Boc-N-PEG2-MS is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

IC 50

PEGs; Alkyl/ether

References

[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005