Benzoic acid,4-[4-[(2-bromoacetyl)amino]butyl]-

Biological Activity

KRA-333 is a potent and selective KRAS agonist th at binds directly to the GTP/GDP binding pocket of KRAS preventing the cleavage of GTP into GDP and caucusing accumulation of activated GTP-KRAS and suppression of cell growth. KRA-333 promotes apoptosis and autophagic cell death of cancer cells and inhibits growth of mutant KRAS lung cancer in xenografts mice model.