Uses
(
S)-(-)-2′-Amino-1,1′-binaphthalen-2-ol or (
S)-NOBIN, is a non-symmetrically substituted 1,1′-binaphthalene ligand. It can be used as a catalyst in the asymmetric synthesis of unnatural α-alkyl amino acids by phase-transfer catalysis (PTC). (
S)-NOBIN can also be employed as starting material to prepare
N-monoalkyl and
N,
N-dialkyl (
S)-NOBIN analogs by reacting with aldehydes via reductive amination reaction.
N-monoaryl derivatives are obtained from NOBIN via Hartwig?Buchwald arylation reaction.
