Description
FIN56 (1083162-61-1) is a novel inducer of ferroptosis acting via degradation of GPX4 and activation of squalene synthase (leading to CoQ10 depletion, a compound which inhibits ferroptosis via an unknown mechanism).1 FIN56 inhibited glioblastoma growth in vitro and in vivo via induction of ferroptosis as well as lysosomal membrane permeabilization.2
Definition
ChEBI: FIN56 is a fluorene that is N-9H-fluoren-9-ylidenehydroxylamine substituted by N-cyclohexylsulfonyl groups at positions 2 and 7. It induces ferroptosis via degradation of GPX4 and also binds and activates squalene synthase. It has a role as a ferroptosis inducer and an EC 1.11.1.9 (glutathione peroxidase) inhibitor. It is a member of fluorenes, a ketoxime and a sulfonamide. It is functionally related to a 9-hydroxyiminofluorene-2,7-disulfonamide.
Biochem/physiol Actions
Ferroptosis inducer 56 (FIN56) is a member of the class 3 ferroptosis inducers.
References
[1] KENICHI SHIMADA. Global survey of cell death mechanisms reveals metabolic regulation of ferroptosis[J]. Nature chemical biology, 2016, 12 7: 497-503. DOI:
10.1038/nchembio.2079[2] XIN ZHANG. FIN56, a novel ferroptosis inducer, triggers lysosomal membrane permeabilization in a TFEB-dependent manner in glioblastoma.[J]. Journal of Cancer, 2021, 12 22: 6610-6619. DOI:
10.7150/jca.58500
