GBR 12783 (10 mg/kg; intraperitoneal injection; for 100 minutes; male Sprague-Dawley rats) treatment reinforces specifically dopamine transmission only at synapses instantaneously active, increases hippocampal ACh release and improves memory performance in a passive avoidance task[1].
| Animal Model: | Male Sprague-Dawley rats (180-200 g)[1] |
| Dosage: | 10 mg/kg |
| Administration: | Intraperitoneal injection; for 100 minutes |
| Result: | For a moderate electric shock intensity (0.4 mA), improveed retention performance, increased hippocampal acetylcholine release in vivo.
|
