Description
W140 is the inactive enantiomer of the sphingosine-1-phosphate receptor 1 (S1P
1) antagonist W146 .
1 It only weakly binds to S1P
1 (K
i = 4.6 μM for the human receptor). W140 has been used as a negative control
in vitro and
in vivo in the study of S1P
1 signaling.
1,2
References
1. Sanna, M.G., Wang, S.K., Gonzalez-Cabrera, P.J., et al.
Enhancement of capillary leakage and restoration of lymphocyte egress by a chiral S1P1 antagonist in vivo Nat. Chem. Biol. 2(8),434-441(2006).
2. Li, C., Chi, X.X., Xie, W., et al.
Sphingosine 1-phosphate receptor 2 antagonist JTE-013 increases the excitability of sensory neurons independently of the receptor J. Neurophysiol. 108(5),1473-1483(2012).
