D-lactosyl-1-1'-N-octanoyl-L-threo-sphingosine

Uses

C8 L-threo-Lactosyl(β) Ceramide (d18:1/8:0) may be used to disrupt brain-derived neurotropic factor (BDNF)-induced integrin clustering.

General Description

C8 L-threo-Lactosyl(β) Ceramide (d18:1/8:0) is a synthetic glycosphingolipid (GSL) with nonnatural stereochemistry.

Biochem/physiol Actions

C8 L-threo-Lactosyl(β) Ceramide (d18:1/8:0) is a caveolar uptake inhibitor, which blocks SV40 virus infection. It also prevents E1-integrin activation and downstream signaling. C8 L-threo-Lactosyl(β) Ceramide (d18:1/8:0) can deter the aggregation of lipids and proteins into glycosphingolipids (GSLs) and cholesterol-enriched microdomains (rafts) at the plasma membrane (PM).