25,26,26,26,27,27-hexadeuterocholest-5-ene-3,27-diol

Uses

27-Hydroxycholesterol-d6 is used in pharmacological studies of cerebral accumulation of dietary derivable plant sterols showing that they do not interfere with memory and anxiety related behaviour in Abcg5-/-mice.

Biological Activity

27-hydroxycholesterol is known to induce breast cancer cell proliferation and metastatic progression in experimental models. It might serve as a ligand for liver X receptors (LXR) and farnesoid X-activated receptors (FXRs). 27-hydroxycholesterol controls the action of hydrocymethylglutaryl-CoA reductase. It promotes cholesterol efflux from the vascular endothelium.