TetroMycin A

Uses

Tetromycin A is an antibiotic against antibiotic resistant and susceptible gram-positive bacteria including MRSA.

Uses

Tetromycin A is an unusual tetronic acid, structurally related to kijanimicin, chlorothricin, saccharocarcin, tetrocarcin and versipelostatin. Tetromycin A has pronounced activity against antibiotic susceptible and resistant Gram positive bacteria including MRSA. Limited availability has restricted further investigation of this metabolite in the literature. Several members of this class have received considerable literature focus. Versipelostatin inhibits transcription from the promoter of GRP78, a gene that is activated as part of a stress signalling pathway under glucose deprivation resulting in unfolded protein response (UPR). The UPR-inhibitory action is seen only in conditions of glucose deprivation and causes selective and massive killing of the glucose-deprived cells. Tetrocarcin A appears to target the phosphatidylinositide-3'-kinase/Akt signalling pathway.

Biological Activity

tetromycin a, as an unusual tetronic acid, is a tetronic acid-based antibiotic. it is structurally related to saccharocarcin, chlorothricin, tetrocarcin, kijanimicin and versipelostatin and has been shown to be active against antibiotic resistant and susceptible gram-positive bacteria including methicillin-resistant staphylococcus aureus (mrsa). mrsa is a strain of bacteria which cannot be killed by a wide range of antibiotics, including methicillin, penicillin, and oxacillin, and causes infections in different parts of the body. the derivatives of tetromycin have been found to inhibit the cysteine protease cathepsin l with ki values in the low micromolar range and have anti-trypanosomal activity. tetromycin a probably targets the phosphatidylinositide-3'-kinase/akt signaling pathway.akt, a downstream factor in the phosphatidylinositide-3'-kinase-dependent pathway, mediates a variety of biological responses, including protein synthesis, glucose uptake and the regulation of proliferation and apoptosis, which presumably contributes to acquisition of malignant properties of human cancers [1].

References

[1]. nakajima, h., sakaguchi, k., fujiwara, i., mizuta, m., tsuruga, m., magae, j., & mizuta, n. apoptosis and inactivation of the pi3-kinase pathway by tetrocarcin a in breast cancers. biochemical and biophysical research communications. 2007; 356(1): 260-265.