Description
(±)12(13)-DiHOME-d4 is intended for use as an internal standard for the quantification of 12(13)-DiHOME by GC- or LC-MS. 12(13)-DiHOME is the diol form of 12(13)-EpOME, a cytochrome P450-derived epoxide of linoleic acid also known as isoleukotoxin.1 It is formed from 12(13)-EpOME by soluble epoxide hydrolase (sEH) in neutrophils.2WARNING This product is not for human or veterinary use.
References
[1] JESSICA F. GREENE. Metabolism of Monoepoxides of Methyl Linoleate: Bioactivation and Detoxification[J]. Archives of biochemistry and biophysics, 2000, 376 2: Pages 420-432. DOI:
10.1006/abbi.2000.1753[2] MEHRAN F. MOGHADDAM. Bioactivation of leukotoxins to their toxic diols by epoxide hydrolase[J]. Nature Medicine, 1997, 3 5: 562-566. DOI:
10.1038/nm0597-562[3] SANDRA GOUVEIA-FIGUEIRA. Characterisation of (R)-2-(2-Fluorobiphenyl-4-yl)-N-(3-Methylpyridin-2-yl)Propanamide as a Dual Fatty Acid Amide Hydrolase: Cyclooxygenase Inhibitor.[J]. PLoS ONE, 2015: e0139212. DOI:
10.1371/journal.pone.0139212
