Uses
Morpholine, 2,6-diMethyl-, (2R,6R)- is an isomerizing agent that converts (2S,6S)-2,6-dimethylmorpholine to (2R,6R)-2,6-dimethylmorpholine.
Synthesis
Morpholine, 2,6-diMethyl-, (2R,6R)- was prepared efficiently by O-alkylation of (R)-ethyl lactate with the O-trifluoromethylsulphonyl derivative of (S)-ethyl lactate
[1].
References
[1] Licandro, E., Maiorana, S., Papagni, A., Pryce, M., Gerosa, A. Z., & Riva, S. (1995). Asymmetric synthesis of (−)-(2R, 6R)-2,6-dimethylmorpholine. Tetrahedron Asymmetry, 6(8), 1891–1894.
https://doi.org/10.1016/0957-4166(95)00245-k
