3-Ethynylimidazo[1,2-b]pyridazine

Uses

3-Ethynylimidazo[1,2-b]pyridazine is used as an intermediate of Ponatinib, a BCR-ABL tyrosine kinase inhibitor anticancer drug used in the treatment of chronic myeloid leukaemia (CML) and Philadelphia Chromosome-Positive Acute Lymphoblastic Leukemia (Ph+ ALL).

Application

3-Ethynylimidazo[1,2-b]pyridazine, a reactive heterocyclic building block, acts as a key intermediate for synthesizing antitumor drugs (e.g., ponatinib), designing bioactive derivatives, developing organic optoelectronic materials, and serving as an impurity reference standard for pharmaceutical quality control.