Synthesis
Using 5,6-dimethoxyindanone as starting material, a global demethylation reaction was carried out in dichloromethane solvent with the addition of an excess of boron tribromide (BBr3) to afford the crude product 5,6-dihydroxyindan-1-one (crude product 1) in 100% reaction yield (see Scheme 1). The crude product obtained did not require further purification and could be used directly in the subsequent reaction steps.
References
[1] Patent: WO2008/94896, 2008, A1. Location in patent: Page/Page column 13
[2] Bioorganic and Medicinal Chemistry Letters, 2007, vol. 17, # 15, p. 4308 - 4315
[3] Bioorganic and Medicinal Chemistry Letters, 2007, vol. 17, # 20, p. 5665 - 5670
[4] Patent: WO2004/80973, 2004, A1. Location in patent: Page 133
[5] RSC Advances, 2015, vol. 5, # 34, p. 26596 - 26603
