2-Methyl-2-(3-bromopropyl)-1,3-dioxolane

Uses

2-Methyl-2-(3-bromopropyl)-1,3-dioxolane is used as a alkylating agentsfor attaching a 4-ketopentyl group to various nucleophiles; the derived organometallic reagents attach this group to electrophilic centers such as carbonyl groups; the major use has been for synthesis of monoprotected 1,5- and 1,6-diketones and related 1,n difunctional compounds.

Synthesis

2-Methyl-2-(3-bromopropyl)-1,3-dioxolane is synthesized by acetalization of the 5-halo-2-pentanone (made by opening 2-acetylbutyrolactone with HX).

storage

Store at <=0 °C; use in a fume hood.