Uses
(
R)-2-Piperazinecarboxylic acid dihydrochloride can be used as a starting material for the synthesis of (
R)-enantiomers of anthramycin analogs, which are potential antiproliferative agents. It can also be employed in the preparation of piperazinemethanol chiral ligands, which can be utilized in the enantioselective borane reduction of aromatic ketones, ketimine, and oxime ether.
Synthesis
As a method for the preparation of racemic 2-piperazine carboxylic acids by optical splitting, it is known to use cyclic camphorsulfonic acid as a splitting agent, racemic 2-piperazine carboxylic acids and cyclic camphorsulfonic acid are made to be dissolved in a solvent and the resultant solution is treated with activated charcoal to remove the color, after which (R)-piperazine-2-carboxylic acid dihydrochloride is precipitated.
