Uses
Used for the purification of O-linked glycoproteins.
Uses
Lectin from
Arachis hypogaea (peanut) has been used:
- to detect Thomson-Friedenreich antigen
- as a component in PBS to study its effects on cell viability
- to study its ability to block the binding site
General Description
Peanut lectin (PNA) is a lectin or an agglutinin from the legume,
Arachis hypogaea, found in peripheral venous blood in humans after ingestion of peanuts. PNA lectin is specific to the galactosyl (β-1,3)
N-acetylgalactosamine.
Biochem/physiol Actions
Lectin is known to be useful in glycoconjugate characterizing, imaging and targeting. Its use in a microarray assay, enable efficient glycome profiling. This is because of its specific interaction with oligosaccharides, glycoproteins and glycolipids. In plants and fungi, lectin defends against pathogens/feeders. Lectin participates in host recognition and tissue adhesion, thereby aids in the pathogenesis of microorganism.
