Starburst(R) (PAMAM) dendrimer, generation 2.5

Uses

PAMAM-OH dendrimer can be used to formulate poorly water-soluble drugs to increase water solubility, and therefore enhance the bioavailability of these drugs. It can also be applied to catalysts and organic molecules, where dendrimers function as solubility enhancers and modifiers.

General Description

PAMAM-OH (poly(amidoamine) dendrimers are highly branched core-shell nanostructures with surface hydroxyl groups. The presence of hydroxyl groups on the surface of the PAMAM-OH dendrimer molecule leads to stronger interaction with the components of the cell membrane via the formation of hydrogen bonds. This type of interaction can modify the properties and function of cell membranes. PAMAM-OH dendrimers also have an advantage over PAMAM dendrimers in terms of cytotoxicity and aggregation problems because of the absence of amine functionality.

References

[1] TISHA C. KING HEIDEN . Developmental toxicity of low generation PAMAM dendrimers in zebrafish[J]. Toxicology and applied pharmacology, 2007, 225 1: Pages 70-79. DOI: 10.1016/j.taap.2007.07.009
[2] SISI LAI. Liposomes for effective drug delivery to the ocular posterior chamber.[J]. Journal of Nanobiotechnology, 2019, 17 1: 64. DOI: 10.1186/s12951-019-0498-7
[3] LAMBERT BODEWEIN . Differences in toxicity of anionic and cationic PAMAM and PPI dendrimers in zebrafish embryos and cancer cell lines[J]. Toxicology and applied pharmacology, 2016, 305: Pages 83-92. DOI: 10.1016/j.taap.2016.06.008