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3-((3-Cholamidopropyl)dimethylammonium)-1-propanesulfonate

3-((3-Cholamidopropyl)dimethylammonium)-1-propanesulfonate Structure
3-((3-Cholamidopropyl)dimethylammonium)-1-propanesulfonate
  • CAS No.75621-03-3
  • Chemical Name:3-((3-Cholamidopropyl)dimethylammonium)-1-propanesulfonate
  • CBNumber:CB4165631
  • Molecular Formula:C32H58N2O7S
  • Formula Weight:614.88
  • MOL File:75621-03-3.mol
3-((3-Cholamidopropyl)dimethylammonium)-1-propanesulfonate Property
  • Melting point: :156-158°C (dec.)
  • Density  :1.01 g/mL at 20 °C
  • refractive index  :1.6900 (estimate)
  • storage temp.  :-20°C
  • solubility  :H2O: 50 mg/mL at 20 °C, clear, colorless
  • form  :Crystalline Powder
  • color  :White
  • Odor :Odorless
  • PH Range :6
  • Water Solubility  :Soluble in water (10 mg/ml). Soluble in DMF and hot methanol.
  • Sensitive  :Hygroscopic
  • Merck  :2044
  • Stability: :Moisture Sensitive: Hydroscopic
  • InChIKey :UMCMPZBLKLEWAF-RFCNGIAKSA-N
  • FDA UNII :QBP25342AG
Safety
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal wordDanger
  • Hazard statements H315-H319-H335
  • Precautionary statements P261-P280a-P304+P340-P305+P351+P338-P405-P501a
3-((3-Cholamidopropyl)dimethylammonium)-1-propanesulfonate Price More Price(50)
  • Brand: Sigma-Aldrich
  • Product number: 220201
  • Product name : CHAPS,MolecularBiologyGrade-CAS75621-03-3-Calbiochem
  • Purity: CAS75621-03-3isazwitterionicdetergentthatcombinesfeaturesofbilesalts
  • Packaging: 1 g
  • Price: $57.53
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  • Product name : CHAPS,MolecularBiologyGrade-CAS75621-03-3-Calbiochem
  • Purity: CAS75621-03-3isazwitterionicdetergentthatcombinesfeaturesofbilesalts
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  • Product name : CHAPS,MolecularBiologyGrade-CAS75621-03-3-Calbiochem
  • Purity: CAS75621-03-3isazwitterionicdetergentthatcombinesfeaturesofbilesalts
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  • Brand: Sigma-Aldrich
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  • Product name : CHAPS,MolecularBiologyGrade-CAS75621-03-3-Calbiochem
  • Purity: CAS75621-03-3isazwitterionicdetergentthatcombinesfeaturesofbilesalts
  • Packaging: 25 g
  • Price: $558.7
  • Updated: 2021/12/16
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  • Brand: Sigma-Aldrich
  • Product number: 220201
  • Product name : CHAPS,MolecularBiologyGrade-CAS75621-03-3-Calbiochem
  • Purity: CAS75621-03-3isazwitterionicdetergentthatcombinesfeaturesofbilesalts
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3-((3-Cholamidopropyl)dimethylammonium)-1-propanesulfonate Chemical Properties,Usage,Production

  • Chemical Properties White crystalline powder
  • Uses A non-denaturing zwitterionic detergent for membrane biochemistry
  • Uses Buffer; zwitterionic nondenaturing detergent for solubilizing membrane proteinsCHAPS is used in the laboratory to dissolve biological macromolecules such as proteins. It acts as a non-denaturing solvent used in purification of membrane proteins. It is also useful in conjunction with nonionic detergents like Triton X-100. Further, it is used as a non-denaturing zwitterionic detergent for membrane biochemistry.
  • General Description
    CHAPS is a stabilizing agent that can be used to prevent aggregation, precipitation or proteolysis of proteins in solution.
  • Biological Activity CHAPS is a zwitterionic nondenaturing detergent for solubilizing membrane proteins.
  • Purification Methods Triturate this zwitterionic detergent (~50g) with MeOH (200ml), then triturate it with Me2CO (500mL), collect it by vacuum filtration and dry it thoroughly at ~20o. Recrystallise it at 0o from absolute MeOH followed by drying in vacuo to constant weight. It should give one spot with RF 0.32 by TLC on silica gel G in 95% MeOH/5% NH4OH and visualized with iodine vapour; the tertiary amine precursor has RF 0.40. It has low UV absorption (1% in H2O: A280nm is 0.029 and A260nm is 0.035), and the CMC (critical micellar concentration) is 8mM. It is soluble in H2O, MeOH, Me2SO but insoluble in Me2CO, MeCN, hexane, toluene and xylene. [Hjelmeland et al. Anal Biochem 130 72 1983, Matuo et al. Methods Enzymol 198 155 1991.] CHAPSO (3-[(3-cholamidopropyl)dimethylammonio]-1-propanesulfonate betaine) [82473-24-3] M 630.89, m 184-196o, [ ] D +19o (c 2, H2O), pKEst (1) ~<2 (acidic), pKEst(2) ~9 (basic). Dissolve this zwitterionic detergent (~ 60g) in 40% aqueous MeOH and stir it with the mixed-bed ion-exchange resin RG-501 x 8 (100g, Bio-Rad) until the pH of the supernatant is ~ 7. Filter off the resin and evaporate the filtrate to dryness under reduced pressure. Check for homogeneity by TLC on silica gel G in 95% MeOH/5% NH4OH and visualize the spot with iodine vapour (see CHAPS above). [Hjelmeland et al. Anal Biochem 130 72 1983, Matuo et al. Methods Enzymol 198 155 1991.]
3-((3-Cholamidopropyl)dimethylammonium)-1-propanesulfonate Preparation Products And Raw materials
Raw materials
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75621-03-3, 3-((3-Cholamidopropyl)dimethylammonium)-1-propanesulfonateRelated Search:
  • CHAPS
  • CHAPS (3-((3-CHOLAMIDOPROPYL)DIMETHYLAMMONIO)PROPANESULFONATE)
  • 3-[(3-CHOLAMIDOPROPYL)DIMETHYLAMMONIO]-1-PROPANE SULPHONATE (ULTRAPURE)
  • 3-[(3-CHOLAMIDOPROPYL)DIMETHYLAMMONIO]PROPANESULFONAT(CHAPS)
  • 3-[(3-Cholamidopropyl)dimethylammonio]-1-propanesulphonate (Ultrapure) >99.0%
  • CHAPS, 98+%
  • CHAPS extrapure
  • 1-Propanaminium, N,N-dimethyl-N-(3-sulfopropyl)-3-[[(3a,5b,7a,12a)-3,7,12-trihydroxy-24-oxocholan-24-yl]amino]-, inner salt
  • Cholane, 1-propanaminium deriv.
  • N,N-Dimethyl-N-(3-sulfonatopropyl)-3-[(3α,7α,12α-trihydroxy-24-oxo-5β-cholan-24-yl)amino]propylaminium
  • N,N-Dimethyl-N-(3-sulfonatopropyl)-3-[[3α,7α,12α-trihydroxy-24-oxo-5β-cholan-24-yl]amino]-1-propaneaminium
  • N-[3-(3-Sulfonatopropyldimethylaminio)propyl]-3α,7α,12α-trihydroxy-5β-cholan-24-amide
  • N,N-Dimethyl-N-(3-sulfopropyl)-3-[[(3a,5,7a,12a)-3,7,12-trihydroxy-24-oxocholan-24-yl]amino]-1-propanaminium Inner Salt
  • 3-[(3-Cholanidopropyl)dimethylammonio]-1-propanesulfonate
  • 3-[(3-Cholamidopropyl)dimethylammonio]-1-propane sulfonate ,98%
  • 3-(3-CHOLAMIDOPROPYL)DIMETHYL-AMMONIO-1-PROPANESULFONATE RESEARCH
  • CHAPS-SOL GRADE
  • 3-((3-Cholamidopropy
  • 3-cholamidopropyl)dimethyl-ammonio]-1-propanesulfonate)
  • CHAPS buffer
  • CHAPS, Molecular Biology Grade
  • 3-[(3-cholamidopropyl)dimethylammonio]propane-1-sulfonate
  • 3-((3-Cholamidopropyl)dimethylammonium)-1-propanesulfote
  • CHAPS 100 mM
  • CHAPS, 3-[(3-Chloamidopropyl)dimethyl- ammonium]-1- propanesulfonate
  • 3-[(3-CHOLAMIDOPROPYL)DIMETHYLAMMONIO]-1-PROPANESULFONATE
  • 3-[(3-CHOLAMIDOPROPYL)DIMETHYLAMMONIO]-1-PROPANE SULPHONATE
  • 3-((3-CHOLAMIDOPROPYL)DIMETHYLAMMONIO)PROPANESULFONATE
  • 3-((3-cholamidopropyl)dimethylammonium)-1-propanesulfonate
  • 3-[(3-Chloromidopropyl)dimethylammonio]-1-propanesulfonate
  • CHAPS 3-[(3-Cholamidopropyl)dimethylammonio]-1-propanesulfonate
  • CHAPS Solution
  • CHAPS ELECTROPHORESIS REAGENT
  • Chaps3-[3-(Cholamidopropyl)Dimethylamonio]-1-Propanesulfonate
  • 3-[(3-Cholamidopropyl)dimethylammonio]propanesulfonic acid
  • CHAPS,HighPurity
  • 3-(3-(cholamidopropyl)dimethyl
  • Cholamidopropyl)dimethylammonio]-1-propanesulfonate
  • 1-Propanaminium, N,N-dimethyl-N-(3-sulfopropyl)-3-(3.alpha.,5.beta.,7.alpha.,12.alpha.)-3,7,12-trihydroxy-24-oxocholan-24-ylamino-, inner salt
  • CHAPS,CRYSTALLINEPOWDER,ULTRAPURE
  • TREND
  • 3-((3-Cholamidopropyl)dimethylammonium)-1-propanesulfonate (CHAPS)
  • 3-[(3-cholaMidopropyl)diMethylaMMonio]propanesulfonate(CHAPS)
  • N,N-DiMethyl-N-(3-sulfopropyl)-3-[[(3α,5β,7α,12α)-3,7,12-trihydroxy- 24-oxocholan-24-yl]aMino]-1-propanaMiniuM Inner Salt
  • 3-(Dimethyl(3-((4R)-4-((3R,5S,7R,10S,12S,13R,17R)-3,7,12-trihydroxy-10,13-dimethylhexadecahydro-1H-cyclopenta[a]phenanthren-17-yl)pentanamido)propyl)ammonio)propane-1-sulfonate
  • CHAPS 100 mM solution
  • CHAPS Vetec(TM) reagent grade, 96%
  • CHAPS, >=99%
  • BRADFORD REAGENT BIOTECHNOLOGY GRADE
  • 3-((3-((4R)-4-((10S,13R,17R)-10,13-DiMethylhexadecahydro-1H-cyclopenta[a]phenanthren-17-yl)pentanaMido)propyl)diMethylaMMonio)propane-1-sulfonate
  • MEDIABAG ST FOR 3375 ML BPW
  • MEDIABAG ST FOR 4000 ML BPW
  • MEDIABAG ST FOR 450ML BPW 10 X10 ST
  • SMMP MEDIUM CONC.
  • TSA PETRI 9CM
  • 3-[(3-Cholamidopropyl)dimethylammonio]-1-propanesulfonate &gt
  • 3-((3-Cholamidopropyl)dimethylammonium)-1-propanesulfonate ISO 9001:2015 REACH
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