Description
Matrix metalloproteinase-12 (MMP-12) is a zinc-dependent metalloproteinase and member of the MMP protein family, which has roles in extracellular matrix (ECM) degradation.1 It is composed of an N-terminal proenzyme domain, a catalytic domain that contains the zinc-binding motif, and a hemopexin-like C-terminal domain. MMP-12 is a secreted protease expressed by macrophages. It is activated by the loss of the N-terminal proenzyme domain, and this active enzyme is further processed to mature MMP-12 via loss of the C-terminal domain. Levels of MMP-12 are increased in sputum from patients with chronic obstructive pulmonary disease (COPD).2 Plasma levels of MMP-12 are increased and positively associated with atherosclerosis and adverse coronary events in patients with type 2 diabetes mellitus.3 Tumor levels of MMP-12 are positively correlated with tumor size and poor overall survival in patients with hepatocellular carcinoma.4 Cayman’s MMP-12 (C-Term) Rabbit Monoclonal Antibody (Clone RM381) can be used for immunohistochemistry (IHC) and Western blot (WB) applications.WARNING This product is not for human or veterinary use.
