Description
Cholesteryl linoleate-d11 is intended for use as an internal standard for the quantification of cholesteryl linoleate (Item No. 22597) by GC- or LC-MS. Cholesteryl linoleate is a pro-atherogenic cholesterol ester.1,2 It has been found in the plasma membrane of macrophages as a component of LDL, where it undergoes oxidation to form cholesteryl linoleate hydroperoxides (Item No. 48001).1 Cholesteryl linoleate levels are increased in apoB-lipoproteins and positively correlated with hepatic cholesterol levels and the number of atherosclerotic lesions in transgenic mice overexpressing human ABCA1.2 Lipoprotein levels of cholesteryl linoleate are increased and associated with lipid radical formation in patients with β-thalassemia.3WARNING This product is not for human or veterinary use.
References
[1] YOSHITAKA TAKAHASHI . Selective uptake and efflux of cholesteryl linoleate in LDL by macrophages expressing 12/15-lipoxygenase[J]. Biochemical and biophysical research communications, 2005, 338 1: Pages 128-135. DOI:
10.1016/j.bbrc.2005.07.182[2] CHARLES W JOYCE. ABCA1 overexpression in the liver of LDLr-KO mice leads to accumulation of pro-atherogenic lipoproteins and enhanced atherosclerosis.[J]. The Journal of Biological Chemistry, 2006, 281 44: 33053-33065. DOI:
10.1074/jbc.m604526200[3] PAKAWIT LERKSAIPHENG . Kinetics of lipid radical formation in lipoproteins from β-thalassemia: Implication of cholesteryl esters and α-tocopherol[J]. Biomedicine & Pharmacotherapy, 2022, 154: Article 113624. DOI:
10.1016/j.biopha.2022.113624
