Description
Hexa-D-arginine is an inhibitor of the proprotein convertase furin (Ki = 100 nM).1 It also inhibits West Nile virus nonstructural protein 3 (NS3) protease (Ki = 478 nM). Hexa-D-arginine (1 µg/ml) reduces the proliferation, invasion, and migration of SW 1990 and PaTu 8988 pancreatic cancer cells, as well as decreases the levels of N-cadherin and vimentin and increases E-cadherin levels, markers of the epithelial-to-mesenchymal transition (EMT), in the same cells.2 It improves survival in a rat model of anthrax toxemia induced by the anthrax toxins protective antigen and lethal factor.3WARNING This product is not for human or veterinary use.
References
[1] SERGEY A SHIRYAEV. Cleavage targets and the D-arginine-based inhibitors of the West Nile virus NS3 processing proteinase.[J]. Biochemical Journal, 2006: 503-511. DOI:
10.1042/bj20051374[2] MENG ZHOU. Furin inhibitor D6R suppresses epithelial-mesenchymal transition in SW1990 and PaTu8988 cells via the Hippo-YAP signaling pathway.[J]. Oncology Letters, 2018: 3192-3196. DOI:
10.3892/ol.2017.7672[3] MIROSLAV S SARAC. Protection against anthrax toxemia by hexa-D-arginine in vitro and in vivo.[J]. Infection and Immunity, 2004, 72 1: 602-605. DOI:
10.1128/iai.72.1.602-605.2004
