Decanamide, N-[(1R,2S)-2-hydroxy-1-(4-morpholinylmethyl)-2-phenylethyl]-, hydrochloride (1:1), rel-

Description

DL-erythro-PDMP is a mixture of ceramide analogs that contains two of the four possible stereoisomers of PDMP : D-erythro-(1S,2R)-PDMP and L-erythro-(1R,2S)-PDMP.^1,2 It protects glucosylceramide (GlcCer) synthase from degradation and increases the level of ceramide in MDCK cells when used at a concentration of 40 μM.² Unlike DL-threo-PDMP, DL-erythro-PDMP does not inhibit GlcCer synthase, but it does inhibit UDP galactose:ceramide galactosyltransferase by 27% in mouse brain microsomes when used at a concentration of 100 μM.³ It inhibits the growth of isolated rabbit skin fibroblasts when used at a concentration of 50 μM but is cytotoxic at concentrations higher than 50 μM.⁴ [Matreya, LLC. Catalog No. 1755]

References

1. Vunnam, R.R., and Radin, N.S. Analogs of ceramide that inhibit glucocerebroside synthetase in mouse brain Chem. Phys. Lipids 26(3),265-278(1980).
2. Abe, A., Radin, N.S., and Shayman, J.A. Induction of glucosylceramide synthase by synthase inhibitors and ceramide Biochim. Biophys. Acta 1299(3),333-341(1996).
3. Inokuchi, J.i., and Radin, N.S. Preparation of the active isomer of 1-phenyl-2-decanoylamino-3-morpholino-1-propanol, inhibitor of murine glucocerebroside synthetase J. Lipid Res. 28(5),565-571(1987).
4. Uemura, K., Sugiyama, E., Tamai, C., et al. Effect of an inhibitor of glucosylceramide synthesis on cultured rabbit skin fibroblasts J. Biochem. 108(4),525-530(1990).