Chemical Properties
Clear, colorless to amber liquid.
Chemical Properties
colourless liquid
Uses
Experimentally as mutagen, teratogen, brain carcinogen.
Uses
Methyl methanesulfonate is a DNA adduct that adds methyl groups to Dan at 7-guanine, 3-guanine and 3-adenine.
Definition
ChEBI: A methanesulfonate ester resulting from the formal condensation of methanesulfonic acid with methanol.
General Description
Colorless to amber liquid.
Air & Water Reactions
Water soluble.
Reactivity Profile
Methyl methanesulfonate is incompatible with strong oxidizing agents, strong acids and strong bases.
Fire Hazard
Methyl methanesulfonate is combustible.
Safety Profile
Confirmed carcinogen
with carcinogenic and neoplastigenic data.
Poison by ingestion, intraperitoneal,
intravenous, and subcutaneous routes.
Human mutation data reported.
Experimental teratogenic and reproductive
effects. When heated to decomposition it
emits toxic fumes of SOx.
Potential Exposure
Research chemical and cancer drug.
No longer produced commercially in the United States.
Carcinogenicity
Methyl methanesulfonate is reascarcinogen based on sufficient evi
onably anticipated to be a human dence of carcinogenicity from studies in experimental animals.
Shipping
UN2810 Toxic liquids, organic, n.o.s., Hazard
Class: 6.1; Labels: 6.1-Poisonous materials, Technical
Name Required.
Purification Methods
Purify the ester by careful fractionation and collecting the middle fraction. Suspected CARCINOGEN. Note that MeSO3H has b 167-167.5o/10mm and methanesulfonic anhydride has b 138o/10mm)—both are possible impurities. [Beilstein 4 IV 11.]
Incompatibilities
Incompatible with oxidizers (chlorates,
nitrates, peroxides, permanganates, perchlorates, chlorine,
bromine, fluorine, etc.); contact may cause fires or explosions. Keep away from alkaline materials, strong bases,
strong acids, oxoacids, epoxides. Esters are generally
incompatible with nitrates. Moisture may cause hydrolysis
or other forms of decomposition
Waste Disposal
It is inappropriate and possibly dangerous to the environment to dispose of lab chemicals or expired or waste drugs and pharmaceuticals by
flushing them down the toilet or discarding them to the
trash. Household quantities of expired or waste pharmaceuticals may be mixed with wet cat litter or coffee
grounds, double-bagged in plastic, discard in trash.
Larger quantities shall carefully take into consideration
applicable DEA, EPA, and FDA regulations. If possible
return the pharmaceutical to the manufacturer for proper
disposal being careful to properly label and securely
package the material. Alternatively, the waste pharmaceutical shall be labeled, securely packaged, and transported
by a state licensed medical waste contractor to dispose by
burial in a licensed hazardous or toxic waste landfill or
incinerator.
