S-[2-(diethylamino)ethyl] alpha-phenylbenzeneethanethioate hydrochloride

Originator

Trocinate,Poythress,US,1950

Manufacturing Process

The following procedure is described in US Patent 2,510,773: To an ice-cold solution of 13.3 grams of 2-diethylaminoethanethiol in 100 cc of dry benzene is slowly added a solution of 23.05 grams of diphenylacetyl chloride in 200 cc of dry benzene. The mixture is stirred 2 hours, then heated to dissolve the fine white solid that is formed. Upon cooling 31.3 grams of 2- diethylaminoethyl diphenylthiolacetate hydrochloride precipitates. It recrystallizes from a mixture of benzene and petroleum ether (BP 60° to 70°C) as rosettes of tiny needles and melts at 129° to 130°C. From a mixture of absolute ethanol and ethyl acetate it recrystallizes as large, almost transparent prisms.

brand name

Tifenamil is INN.

Therapeutic Function

Spasmolytic