ChemicalBook CAS DataBase List Suvratoxumab

Suvratoxumab

Product NameSuvratoxumab
CAS1629620-18-3
CBNumberCB38081022
MW0
MOL FileMol file
MSDS FileSDS

Chemical Properties

form	Liquid
color	Colorless to light yellow
FDA UNII	4L1997J4DF

Suvratoxumab Price

Product number	Packaging	Price	Product description	Buy
Usbiological 592220	100ug	$829	Suvratoxumab ≥95%	Buy
ChemScene CS-0628020	1mg	$325	Suvratoxumab 98.79%	Buy
ChemScene CS-0628020	5mg	$845	Suvratoxumab 98.79%	Buy
ChemScene CS-0628020	10mg	$1354	Suvratoxumab 98.79%	Buy
aablocks AA02AOZ7	1mg	$369	Suvratoxumab >98%	Buy

Suvratoxumab Chemical Properties,Usage,Production

Uses

Suvratoxumab (MEDI4893) is a long-acting, high-affinity human anti-α-toxin monoclonal antibody (IgG1κ type). Suvratoxumab potently neutralizes α-toxin, a key S. aureus virulence factor. Suvratoxumab improves survival and reduces lung injury in an immunocompromised mice model of pneumonia. Suvratoxumab also enhances the antibacterial activity of Vancomycin (HY-B0671) or Linezolid (HY-10394)[1][2][3].

in vivo

Suvratoxumab (5, 15, 45 mg/kg; i.p.; single) increases survival rates in an immunocompromised murine pneumonia model^[1].
Suvratoxumab (15 mg/kg; i.p.; single) prophylaxis reduces pulmonary damage and increases macrophage phagocytosis in mice^[1].
Suvratoxumab (15 mg/kg; i.p.; single) prophylaxis improves the effectiveness of antibiotic (vancomycin or linezolid) treatment in mice^[1].

Animal Model:	Specific-pathogen-free, 7- to 9-week-old, female C57BL/6J mice (immunocompromised pneumonia model)^[1].
Dosage:	5, 15, 45 mg/kg
Administration:	Intraperitoneal injection; single
Result:	Resulted in dose-dependent increases in survival rates and reductions in bacterial CFU.

Animal Model:	Specific-pathogen-free, 7- to 9-week-old, female C57BL/6J mice (immunocompromised pneumonia model)^[1].
Dosage:	15 mg/kg
Administration:	Intraperitoneal injection; single
Result:	Prophylaxis protected the lungs of S. aureus-infected immunocompromised mice from α toxin-mediated damage.

References

[1] Hua L, et al. MEDI4893* Promotes Survival and Extends the Antibiotic Treatment Window in a Staphylococcus aureus Immunocompromised Pneumonia Model. Antimicrob Agents Chemother. 2015 Aug;59(8):4526-32. DOI:10.1128/AAC.00510-15
[2] Yu XQ, et al. Safety, Tolerability, and Pharmacokinetics of MEDI4893, an Investigational, Extended-Half-Life, Anti-Staphylococcus aureus Alpha-Toxin Human Monoclonal Antibody, in Healthy Adults. Antimicrob Agents Chemother. 2016 Dec 27;61(1):e01020-16. DOI:10.1128/AAC.01020-16
[3] Oganesyan V, et al. Mechanisms of neutralization of a human anti-α-toxin antibody. J Biol Chem. 2014 Oct 24;289(43):29874-80. DOI:10.1074/jbc.M114.601328

Preparation Products And Raw materials

Suvratoxumab Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
ShangHai Biochempartner Co.,Ltd	177-54423994 17754423994	2853530910@QQ.com	China	7998	62
Guangzhou Hongyuan Chemical Co.,Ltd	15817493340	981810490@qq.com	China	1577	58
Wuhan Chemstan Biotechnology Co., Ltd.	027-65317797 15926423062	422450190@qq.com	China	10302	58
Beijing Jin Ming Biotechnology Co., Ltd.	010-60605840	psaitong@jm-bio.com	China	27626	58
Biolab Reagents	027-65279366 18108604356	products@biolabreagent.com	China	9864	58
Wuhan Jingkangen Biomedical Technology Co., Ltd	13720134139 086-15871494362 13720134139	orders@jknbiochem.com	China	7284	58
Shanghai Yifei Biotechnology Co. , Ltd.	021-65675885 18964387627	customer_service@efebio.com	China	11963	58
Wuhan Acumen Bio-Technology Co.,ltd	027-027-16602739303 16602739303	673003916@qq.com	China	4737	58
Changsha Fuzhen Biotechnology Co.，LTD	15111215862 18229892877	3062105966@qq.com	China	5571	58
Olix ( Hubei) Pharmaceutical Technology Co., Ltd	17316404525 17316404525	209533805@qq.com	China	9772	58

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