SHH, mouse, C-terminal histidine-tagged

Uses

Sonic hedgehog peptide from mouse has been used for neural differentiation.

Biological Activity

Cell signaling peptide involved in embryonic morphogenic development of several tissues including Hensenμs node, the notochord, and the neural tube.', 'Sonic hedgehog (Shh) has a role in fracture healing and regeneration. The protein associates with its receptor Patched (Ptc-1), de-represses Smoothened (Smo) and activates the Gli family of transcription factors. Mutations in the Shh pathway have been linked to developmental diseases and cancer.