ANTI-HUMAN VON WILLEBRAND FACTOR

Uses

Anti-von Willebrand Factor antibody produced in rabbit has been used for:

• western blot analysis and immunostaining
• immunocytochemistry
• immunohistochemistry
• indirect immunofluorescence

General Description

Human von Willebrand factor (factor VIII R:Ag) is a 270 kDa multimeric plasma gylcoprotein. The von Willebrand factor has functional binding domains to platelet glycoprotein Ib, glycoprotein IIb/IIIa, collagen and heparin. The factor is synthesized by endothelial cells and is also present in platelets and megakaryocytes.

Biochem/physiol Actions

It mediates platelet adhesion to injured vessel walls and serves as a carrier and stabilizer for coagulation factor VIII.