ANTI-NERVE GROWTH FACTOR RECEPTOR (NGFR P75), RAT

Uses

Anti-Nerve growth factor receptor (NGFR p75) antibody produced in rabbit has been used in:

• immunoprecipitation
• immunocytochemistry
• immunohistochemistry
• immunoblotting

General Description

Peptide sequence of the antigen is highly conserved in human (single amino acid substitution) and chicken NGFR p75.

Biochem/physiol Actions

Neurotrophins (NT) are growth factors that are essential for the development and maintenance of the nervous system. One of the receptors that mediate the effects of NTs is the Nerve Growth Factor Receptor/TNFRSF16 (p75NGFR, p75NTR). NGFR mediates the effects of NGF that are important in the survival and differentiation of neurons and neural crest-derived cells, during embryonic and early postnatal development. Expression of NGFR has been associated with favorable prognosis and survival in breast and pancreatic cancers.