Description
Amyloid-β (1-42) (Aβ42) is a neurotoxic 42-amino acid protein fragment found in amyloid plaques in postmortem cerebral cortex from patients with Alzheimer’s disease.1,2,3 Aggregation of Aβ42 results in the formation of neurotoxic fibrils or globular oligomers.1 Aβ42 accumulates in the brain of many transgenic mouse models of Alzheimer’s disease and, in many models, the onset of amyloid deposition positively correlates with deficits in spatial learning and memory.4WARNING This product is not for human or veterinary use.
References
[1] WAHLUND L, COWBURN R, WINBLAD B, et al. Therapeutic Strategies in Alzheimer’s Disease[C]. 1900: 0. DOI:
10.1007/978-1-4615-8149-9_80[2] T IWATSUBO. Visualization of A beta 42(43) and A beta 40 in senile plaques with end-specific A beta monoclonals: evidence that an initially deposited species is A beta 42(43).[J]. Neuron, 1994, 13 1: 45-53. DOI:
10.1016/0896-6273(94)90458-8[3] D. O. T. ALAWODE. Alzheimer’s Disease Biomarkers Revisited From the Amyloid Cascade Hypothesis Standpoint[J]. Frontiers in Neuroscience, 2022. DOI:
10.3389/fnins.2022.837390[4] JOANNA L JANKOWSKY H Z. Practical considerations for choosing a mouse model of Alzheimer’s disease.[J]. Molecular Neurodegeneration, 2017: 89. DOI:
10.1186/s13024-017-0231-7
