Description
Leukotriene D4 (LTD4) is one of the constituents of slow-reacting substance of anaphylaxis (SRS-A) produced by the metabolism of LTC4 by γ-glutamyl transpeptidase.1,2 LTD4-induced bronchoconstriction and enhanced vascular permeability contribute to the pathogenesis of asthma and acute hypersensitivity.3,4 LTD4 is several hundred fold more potent than LTC4 at the cysteinyl-leukotriene 1 (CysLT1) receptor, but they exhibit approximately equal affinity at the CysLT2 receptor.5,6 LTD4 methyl ester is a more lipid soluble form of LTD4. The biological activity of LTD4 methyl ester has not been reported.WARNING This product is not for human or veterinary use.
References
[1] L ORNING B S S Hammarström. Leukotriene D: a slow reacting substance from rat basophilic leukemia cells.[J]. Proceedings of the National Academy of Sciences of the United States of America, 1980, 77 4: 2014-2017. DOI:
10.1073/pnas.77.4.2014[2] S HAMMARSTRÖM K B L Orning. Metabolism of leukotrienes.[J]. Molecular and Cellular Biochemistry, 1985, 69 1: 7-16. DOI:
10.1007/bf00225922[3] PER HEDQVIST. Biological profile of Ieukotrienes C4 and D4[J]. Acta Physiologica, 1980, 110 3: 331-333. DOI:
10.1111/j.1748-1716.1980.tb06676.x[4] BENGT SAMUELSSON. Leukotrienes and Lipoxins: Structures, Biosynthesis, and Biological Effects[J]. Science, 1987, 237 4819. DOI:
10.1126/science.2820055[5] KEVIN R. LYNCH. Characterization of the human cysteinyl leukotriene CysLT1 receptor[J]. Nature, 1999, 399 6738: 789-793. DOI:
10.1038/21658[6] C E HEISE. Characterization of the human cysteinyl leukotriene 2 receptor.[J]. The Journal of Biological Chemistry, 2000, 275 39: 30531-30536. DOI:
10.1074/jbc.m003490200
