Description
Stearoyl-L-carnitine-d
3 (chloride) is intended for use as an internal standard for the quantification of stearoyl-L-carnitine (Item No. 26556) by GC- or LC-MS. Stearoyl-L-carnitine is a naturally occurring long-chain acylcarnitine. It inhibits sodium-dependent [
3H]carnitine uptake in human proximal convoluted tubular (HPCT) cells by 52% when used at a concentration of 500 μM. It also inhibits lecithin:cholesterol acyltransferase activity in rat, but not human, plasma when used at a concentration of 500 μM. Plasma levels of stearoyl-L-carnitine are decreased in patients with chronic fatigue syndrome and increased in patients with end-stage renal disease.
Uses
Stearoyl-L-carnitine-d3 Hydrochloride is labelled Stearoyl Carnitine (S686515), A carnitine ester which was tested for its ability to inhibit protein kinase C (PKC).
References
[1] WEI HUANG . Carnitine transport and its inhibition by sulfonylureas in human kidney proximal tubular epithelial cells[J]. Biochemical pharmacology, 1999, 58 8: Pages 1361-1370. DOI:
10.1016/s0006-2952(99)00219-1[2] BELL F P. Carnitine esters: Novel inhibitors of plasma lecithin: Cholesterol acyltransferase in experimental animals but not in man (Homo sapiens)[J]. International Journal of Biochemistry, 1983, 15 2: Pages 133-136. DOI:
10.1016/0020-711x(83)90053-8
