Description
GPR40 is a seven transmembrane G Protein-coupled receptor with signalling mediated by medium- and long-chain fatty acids.1,2 Found predominantly in the β-cells of pancreatic islets, it has been implicated in the regulation of insulin secretion.3,4 Overexpression of GPR40 in mouse β cells leads to glucose intolerance suggesting a link between GPR40 expression and diabetes.3,4 The receptor has also been identified as a possible mediator of oleate- and linoleate- stimulated proliferation of the human breast cancer cell line, MCF-7.5,6 GPR40 has a calculated mass of 31.4 kDa bases on its amino acid sequence.WARNING This product is not for human or veterinary use.
