Description
Atrial natriuretic peptide (ANP) is an endogenous peptide generated by proteolysis of prepro-ANP that is secreted by cardiomyocytes in the heart.1,2 It has effects on the renal and cardiovascular systems that decrease vasoconstriction, inhibit renin secretion, and increase sodium excretion. In rat kidney cortex ex vivo, exogenous rat ANP inhibits basal renin release in a dose-dependent manner and inhibits renin release induced by isoproterenol (Item No. 15592) with an IC50 value of 58 nM.3 ANP (8 µg/kg) decreases plasma renin activity and cAMP levels in anesthetized rats and increases cGMP levels. It also inhibits arginine vasopressin-induced increases in mean arterial blood pressure in spontaneously hypertensive and control rats when administered intracerebroventricularly at a dose of 150 ng.4 ANP (1-28) (rat) is a 28 amino acid peptide corresponding to the rat protein sequence.WARNING This product is not for human or veterinary use.
References
[1] T.GEOFFREY FLYNN Adolfo J de B Mercedes L de Bold. The amino acid sequence of an atrial peptide with potent diuretic and natriuretic properties[J]. Biochemical and biophysical research communications, 1983, 117 3: Pages 859-865. DOI:
10.1016/0006-291x(83)91675-3[2] MAACK T. Role of atrial natriuretic factor in volume control[J]. Kidney international, 1996, 49 6: Pages 1732-1737. DOI:
10.1038/ki.1996.257[3] K OBANA. Synthetic rat atrial natriuretic factor inhibits in vitro and in vivo renin secretion in rats.[J]. Endocrinology, 1985, 117 3: 1282-1284. DOI:
10.1210/endo-117-3-1282[4] KONRAD STȨPNIAKOWSKI . Central cardiovascular effects of AVP and ANP in normotensive and spontaneously hypertensive rats[J]. Journal of the autonomic nervous system, 1994, 47 1: Pages 33-43. DOI:
10.1016/0165-1838(94)90063-9
