Uses
The direct hydrogenation of 2-Methyl-2-nitropropan-1-ol obtains product 2-amino-2-methyl-1-propanol (AMP-95). AMP-95 is a kind of multifunction additive being widely known by the
people, be widely used in coating and printing ink, metal working fluid, in the industries such as personal nursing and medicine intermediate.
Synthesis
By catalyst 10g (Ti-V-ZSM-5), acetone 58.08g, ammonium hydroxide 20g are
added in 400ml methanol, are warming up to 70
DEG C, hydrogen peroxide (35%) 226.7g is slowly added dropwise,
temperature is maintained to react 1h at 65-75 DEG C, obtain 2- nitros
third after being added dropwise
Alkane reaction solution；Filtering adds in 5g sodium hydroxides to
reaction solution, is warming up to 35 DEG C, formaldehyde (40% aqueous
solution) is added dropwise, drip with
the reaction was continued afterwards 3h, obtains 2-Methyl-2-nitropropan-1-ol.
Purification Methods
Distil it under vacuum and/or crystallise it from pet ether or MeOH. [Astle & Abbott J Org Chem 21 1229 1956, Kambe & Yasuda Bull Soc Chem Jpn 41 1444 1968, Beilstein 1 H 378, 1 III 1546, 1 IV 1604.]
