Uses
Calciseptine, a naturalneurotoxinisolated from the black mamba Dendroaspis p. polylepis venom. Calciseptine consists of 60 amino acids with four disulfide bonds. Calciseptine specifically blocks L-typecalcium channel[1].
IC 50
L-type calcium channel: 15 nM (IC
50)
References
[1] H Schweitz, et al. Calcicludine, a venom peptide of the Kunitz-type protease inhibitor family, is a potent blocker of high-threshold Ca2+ channels with a high affinity for L-type channels in cerebellar granule neurons. Proc Natl Acad Sci U S A. 1994 Feb 1; 91(3): 878–882. DOI:
10.1073/pnas.91.3.878
