ANTI-WRN

Uses

All Prestige Antibodies Powered by Atlas Antibodies are developed and validated by the Human Protein Atlas (HPA) project (www.proteinatlas.org)and as a result, are supported by the most extensive characterization in the industry.

The Human Protein Atlas project can be subdivided into three efforts: Human Tissue Atlas, Cancer Atlas, and Human Cell Atlas. The antibodies that have been generated in support of the Tissue and Cancer Atlas projects have been tested by immunohistochemistry against hundreds of normal and disease tissues and through the recent efforts of the Human Cell Atlas project, many have been characterized by immunofluorescence to map the human proteome not only at the tissue level but now at the subcellular level. These images and the collection of this vast data set can be viewed on the Human Protein Atlas (HPA) site by clicking on the Image Gallery link. To view these protocols and other useful information about Prestige Antibodies and the HPA, visit .

General Description

The Werner syndrome protein (WRN), a RecQ family helicase is mapped to human chromosome 8p12. It is different from the RecQ enzymes as it contains an N-terminal 3′- to 5′-exonuclease domain.

Biochem/physiol Actions

The Werner syndrome protein (WRN) helps in the maintenance of genome and telomere. It maintains the stability of genome, mainly at the time of DNA replication, transcription, recombination and repair of DNA double-stranded breaks (DSBs).