Description
PACAP-related peptide (PRP) is an endogenous 29-amino acid peptide that belongs to the secretin/glucagon superfamily of peptides, which includes secretin (Item No. 24561), glucagon (Item No. 24204), glucagon-like peptide-1 (GLP-1; Item No. 24460), GLP-2 (Item No. 24414), and pituitary adenylate cyclase-activating polypeptide (PACAP; Item Nos. 24769 | 24770).1,2 It is expressed in normal human pancreas and adrenal gland tissue and in some tumors that produce vasoactive intestinal peptide (VIP).3 PRP (1-29) is secreted by CHO-K1 cells that express human recombinant preproPACAP.4WARNING This product is not for human or veterinary use.
References
[1] DAVID VAUDRY. Pituitary adenylate cyclase-activating polypeptide and its receptors: 20 years after the discovery.[J]. Pharmacological Reviews, 2009, 61 3: 283-357. DOI:
10.1124/pr.109.001370[2] JANICE K.V. TAM Billy K C C Leo T O Lee. PACAP-related peptide (PRP)—Molecular evolution and potential functions[J]. Peptides, 2007, 28 9: Pages 1920-1929. DOI:
10.1016/j.peptides.2007.07.011[3] JAN FAHRENKRUG Jens H Thora Buhl. PreproPACAP-derived peptides occur in VIP-producing tumours and co-exist with VIP[J]. Regulatory Peptides, 1995, 58 3: Pages 89-98. DOI:
10.1016/0167-0115(95)00052-d[4] KIMITAKE OKAZAKI. Expression of human pituitary adenylate cyclase activating polypeptide (PACAP) cDNA in CHO cells and characterization of the products[J]. FEBS Letters, 1992, 298 1: Pages 49-56. DOI:
10.1016/0014-5793(92)80020-h
