Uses
All Prestige Antibodies Powered by Atlas Antibodies are developed and validated by the Human Protein Atlas (HPA) project
(www.proteinatlas.org)and as a result, are supported by the most extensive characterization in the industry.
The Human Protein Atlas project can be subdivided into three efforts: Human Tissue Atlas, Cancer Atlas, and Human Cell Atlas. The antibodies that have been generated in support of the Tissue and Cancer Atlas projects have been tested by immunohistochemistry against hundreds of normal and disease tissues and through the recent efforts of the Human Cell Atlas project, many have been characterized by immunofluorescence to map the human proteome not only at the tissue level but now at the subcellular level. These images and the collection of this vast data set can be viewed on the Human Protein Atlas (HPA) site by clicking on the Image Gallery link. To view these
protocols and other useful information about Prestige Antibodies and the HPA, visit .
General Description
HSF1 (heat shock transcription factor 1) is a transcriptional protein, which plays an essential role in the heat shock process. It is a multi-domain protein, which is composed of a helix winged-loop helix DNA binding domain (DBD) in its N-terminal, three leucine zipper domains (LZ1-3), a core regulatory domain, another leucine zipper domain (LZ4), and a C-terminal transcription activation domain.
Biochem/physiol Actions
HSF1 (heat shock transcription factor 1) is capable of controlling the transcription of other genes. It mediates the expression of chaperone proteins, and increases cell survival under thermal stress. It regulates protein homeostasis, thus, determining ageing and longevity. It also functions as a transcription regulator of dystrophin protein, Dp71. This protein is over-expressed in hepatocellular carcinoma (HCC), and thus, has potential as a prognostic marker as well as a therapeutic target in the same. This protein is activated in CAFs (cancer associated fibroblasts), where it promotes maliganancy. Thus, high stromal expression of HSF1 protein in early-stage lung and breast is linked with poor patient prognosis.
